Semax: A Comprehensive Review
🧬 What is Semax?
Semax is a synthetic heptapeptide (a peptide consisting of seven amino acids: Met-Glu-His-Phe-Pro-Gly-Pro). It was developed in the 1980s by the Institute of Molecular Genetics at the Russian Academy of Sciences.
Structurally, it is an analog of a fragment of ACTH (Adrenocorticotropic hormone). However, unlike ACTH, Semax has been modified so that it does not exhibit hormonal activity. Instead, it crosses the blood-brain barrier (BBB) to act almost exclusively on the central nervous system. In Russia and Ukraine, it is an approved medication used to treat strokes, cognitive decline, optic nerve diseases, and even peptic ulcers.
⚙️ Mechanism of Action: How Does it Work?
Semax does not work like a traditional stimulant (e.g., amphetamines or caffeine). Its mechanisms are deeply tied to neuroplasticity and neuromodulation:
- Upregulation of BDNF and NGF: This is Semax’s claim to fame. It rapidly increases the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the hippocampus and forebrain. These proteins are the "fertilizer" of the brain, responsible for the growth, survival, and differentiation of new neurons and synapses.
- Dopaminergic & Serotonergic Modulation: Semax enhances the activity of dopamine and serotonin receptors, leading to an increase in focus, motivation, and mood without depleting neurotransmitter stores.
- Enkephalin Protection: Semax inhibits the enzymes that break down enkephalins (the body's natural painkillers and stress-reducers), which contributes to its anti-anxiety (anxiolytic) properties.
https://media.rankstone.org/bph70122-toc-0001-m.jpg
🧠 Potential Benefits
Based on clinical use and anecdotal reports within the peptide community, the primary benefits include:
- Enhanced Cognition & Focus: Users report a "clear-headed" focus, improved working memory, and faster learning acquisition.
- ADHD Management: Because of its gentle dopaminergic action, many researchers study Semax as an alternative to harsh stimulant medications.
- Neuroprotection & Stroke Recovery: It protects neurons from hypoxic damage (lack of oxygen) and heavy metal toxicity.
- Mood Elevation: Reduction in mental fatigue and a noticeable decrease in anxiety in high-stress situations.
🧪 The Three Variants of Semax
If you are looking at biotech vendors, you will likely see three versions of Semax. Here is the difference:
- Standard Semax: The original Russian formula. Highly effective but has a relatively short half-life and is susceptible to enzymatic breakdown.
- N-Acetyl Semax (NA-Semax): The addition of an acetyl group improves the peptide's stability and dramatically increases its ability to cross the blood-brain barrier.
- N-Acetyl Semax Amidate (NASA): The addition of an amide group at the C-terminus further protects the peptide from enzymatic degradation. This variant has the longest half-life, the best BBB penetration, and is considered the "gold standard" for cognitive enhancement by biohackers.
💉 Administration and Dosage
(Note: Dosages vary based on the variant used and individual research goals).
- Route: Because peptides are destroyed in the GI tract, Semax is primarily administered via intranasal spray (the most common and highly effective method for brain delivery) or Subcutaneous (SubQ) injection.
- Dosage: For intranasal use, typical research doses range from 200mcg to 1,000mcg (1mg) per day. SubQ doses are generally lower due to higher bioavailability.
- Cycling: Because it upregulates BDNF, it is usually cycled (e.g., 4 weeks on, 1-2 weeks off) to prevent receptor downregulation.
https://media.rankstone.org/f04d4fca554d4486458b4285f15c5c787d0c85a5.png.webp
⚠️ Side Effects & Considerations
Semax is generally considered very safe and non-toxic, with a massive therapeutic window. However, some reported side effects include:
- Hair loss (Anecdotal): High levels of BDNF can accelerate the hair growth cycle, which may cause shedding in individuals predisposed to male pattern baldness.
- Irritability/Overstimulation: Usually a result of dosing too high.
- Lethargy: Sometimes experienced when the peptide wears off or if the dose is too high (brain fatigue from over-firing).
https://www.youtube.com/watch?v=__H7kL8McsQ
📚 Top Scientific Studies on Semax
For those who want to dig into the actual literature, here are some of the most pivotal studies demonstrating Semax's efficacy:
1. Semax and BDNF / NGF Expression This foundational study demonstrates how Semax rapidly upregulates BDNF and NGF in the brain, proving its neurogenic properties.
- Study: Semax, an analog of ACTH(4-10) with cognitive-enhancing effects, regulates BDNF and trkB expression in the rat hippocampus.
- Link: PubMed: 16996699
2. Semax in Stroke and Ischemic Recovery A clinical look at how Semax is used to treat acute ischemic stroke, showcasing its neuroprotective capabilities and ability to halt neuronal death.
- Study: Efficacy and safety of Semax in acute ischemic stroke: a randomized controlled trial.
- Link: PubMed: 15798585 (Note: Russian clinical literature)
3. Semax for ADHD and Cognitive Improvement Research highlighting the effects of Semax on attention, memory, and its potential as a treatment for ADHD due to its neuromodulatory effects.
- Study: The use of Semax in the treatment of patients with attention deficit hyperactivity disorder.
- Link: PubMed: 15338690
4. Semax and Dopamine/Serotonin Modulation This study explores how Semax interacts with the brain's monoamine systems, explaining why users feel enhanced motivation and mood.
- Study: Effects of Semax on the monoaminergic systems of the brain.
- Link: PubMed: 18630713
🏁 Conclusion
Semax remains one of the most fascinating peptides in the biotech world. Unlike traditional nootropics that simply push dopamine or acetylcholine, Semax fundamentally alters the brain's environment by promoting actual structural growth and repair via BDNF. Whether for cognitive enhancement or neuroprotection, it is a highly validated peptide worth researching.
Disclaimer: This post is for educational and informational purposes only. Semax is not FDA-approved in the United States. Always conduct your own research and consult with a medical professional before introducing peptides into your protocol.
Modding Tutorial
[GUIDE] How to Make a Rocket League Mod from Scratch (No BakkesMod | Full C++ SDK)
What's up everyone! Today I’m sharing a complete, start-to-finish guide on how to create a Rocket League mod entirely from scratch.
Unlike standard plugins, this does not use BakkesMod. Bypassing BakkesMod gives you absolute, low-level control over the game engine.
Below you will find the required files, the latest offsets, and a written breakdown of the video guide.
🛠️ Prerequisites & Downloads
To follow along, you will need:
- Visual Studio 2022 (with C++ Desktop Development)
- Cheat Engine (for DLL injection and memory viewing)
- Ghidra (for advanced offset/signature finding)
⬇️ Required Project Files: (Click the links below to download the project bases)
📎 RLSDK Generator.zip (8.19 MB)
📎 Mod Template.zip (9.41 MB)
💾 Current Offsets (Epic Games)
If you don't want to find the offsets yourself right now, here are the latest ones for the Epic Games version (as of the latest update). You will need to plug these into the project files.
// --- Rocket League Epic Games Offsets ---
// Global Objects Array
constexpr uintptr_t GObjectsOffset = 0x23F0898;
// Global Names Array
constexpr uintptr_t GNamesOffset = 0x2370850;
📖 Step-by-Step Summary
1. Generating the SDK
Before you can mod the game, you need to generate a Software Development Kit (SDK) specific to the current version of Rocket League.
- Open the RLSDK Generator project in Visual Studio.
- Go to Engine -> Template -> Configuration.cpp.
- Update the GObjectsOffset and GNamesOffset with the values provided above.
- Build the project in Release mode (x64).
- Open Rocket League, open Cheat Engine, and inject your newly built CodeGenerator.dll into RocketLeague.exe.
- A message box will appear saying generation has started. Wait ~20 seconds. Once finished, an RLSDK folder will be generated in your *C:* drive.
2. Fixing the SDK Headers
Open the generated RLSDK folder using VS Code.
- Navigate to SDKHeaders.hpp.
- Add #include "GameDefines.hpp" at the very top of the file.
- Ensure the core files are included before the engine files to prevent compilation errors.
3. Setting Up the Mod Template
- Extract the Mod Template zip.
- Replace the empty RLSDK folder inside the template with the one you just generated.
- Open the Mod Template project in Visual Studio.
- Navigate to Components -> Components -> Core.cpp.
- Update the offsets here as well (they must match the ones used in the generator).
- Build the project, inject the new DLL into the game via Cheat Engine, and if done correctly, a template GUI will appear in-game!
4. Modifying Game Data
You now have the ultimate playground. There are two main ways to modify the game:
- Hooking Functions (Events.hpp): Hook into game functions to edit parameters before they are executed.
- Searching Instances (Instances.hpp): Search all loaded instances by class type or name to edit them dynamically.
(For creating buttons or visual GUI elements, look inside GUI.cpp -> InitMainTab() and copy the existing ImGui examples).
https://img.youtube.com/vi/rFqXtzVUOXs/mqdefault.jpg
🔍 Deep Dive: Finding Offsets Manually & Byte Signatures
Hardcoded offsets break every time Rocket League updates. To make your mod "update-proof", you need to use Byte Signatures (AOBs).
I have created a dedicated video explaining exactly how to dump the game in Ghidra, locate the ByteProperty and MaxObjectsNotConsideredByGC strings to find your GNames and GObjects pointers, and how to use AI to generate flawless signatures.
Watch the advanced Offset & Signature guide here:
Example Signature for GNames: Instead of hardcoding 0x2370850, you scan the memory for this instruction pattern:
// Dynamic GNames Pattern
48 8D 0D ?? ?? ?? ?? 33 D2 41 B8 00 00 08 00
Note: The question marks ?? represent wildcards for memory addresses that change. You can test these signatures directly in Cheat Engine by doing an "Array of byte" scan on executable memory!
💬 Conclusion
This SDK gives you the keys to the Unreal Engine kingdom. You can explore TAGame_classes.hpp to see exactly how Rocket League handles physics, cars, and the ball.
If you guys have any questions, get stuck on compiling, or want me to cover specific features (like drawing hitboxes or manipulating ball velocity) in the next tutorial, drop a reply below!
Happy Modding! 🚗⚽🔥
Devast.io 2 (Unity Clone)
Devast.io 2 - Open Source Unity Clone & Codebase
https://www.youtube.com/watch?v=jer8nw0e1VY
Background
When Devast.io updates started slowing down and the active player base began to drop, a project was started to completely recreate the game in the Unity engine. Originally, the goal was to keep the game alive. However, as time passes and people grow up and move on to other things, it mostly just remains as a nostalgic project.
Instead of letting the files sit unused, the source code is being released publicly for the web archives and anyone in the Devast.io community who wants to mess around with it.
Project Details & Features
The game is unfinished, but a very solid technical foundation was built. Anyone can take this code, fork the repository, and continue working on it or use it to learn Unity.
The current GitHub build includes:
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Networking Base: Multiplayer support is set up using Mirror for Unity, handling the core server/client communication.
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Game Assets: All the original items are loaded and configured in the engine.
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Custom Environments: Custom block textures and 3D models are fully integrated.
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Mechanics: Projectiles, basic combat, and hit registration are set up and working.
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UI System: A fully functional inventory and crafting menu is implemented.
Source Code & Media
The full repository is open-source and free for anyone to use, modify, or study.
DevastMod Archive
DevastMod (Devast.io) - Source Code & Data Archive
https://github.com/yamete-dev/DevastMod
https://media.rankstone.org/DevastMod_banned.png
Project Overview
This thread serves as the factual archive for DevastMod, the first dedicated modding webpage and client extension created for the browser game Devast.io. Prior to this project, using custom scripts in Devast.io required manual configuration through third-party tools like Resource Override. DevastMod was developed to package these scripts into a centralized, accessible web interface and Chrome extension.
The development was divided into two main roles:
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Reverse Engineering & Exploits: Managed by ward0g. This included decrypting the game's packet structure and developing core exploits. Notable patches included the "build on roads" exploit, zoom hacks, the aimbot, and vision modifications (revealing invisible players, hidden mines, and camo).
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Frontend & Infrastructure: Managed by Yamete. This involved building the website, designing the custom user interface, creating the custom themes, and packaging the tool into a public Chrome extension for easy installation.
Archived Features & Media
The GitHub repository contains the full source code, readmes, and asset files. Below is the documented media of the mod's features in action:
- Custom UI & Live Chat: The mod featured a custom game menu and a global live chat system that linked in-game communication across all servers directly to Discord.
https://www.youtube.com/watch?v=7hq9OXWtR5I
- Aimbot & Combat Systems: Automated targeting systems and combat scripts developed for the client.
https://www.youtube.com/watch?v=CVbdtYvojFY
- Custom Player Skins: A custom skin selector was injected into the game UI, allowing players to choose between Default, Athlete, Devil, and Fury skins.
https://media.rankstone.org/skinsBox.png
Community Context (HypR Clan)
DevastMod was closely associated with the HypR clan, which hosted the primary Discord servers for the mod's user base. To accurately archive the community history, the following individuals are documented as key players, testers, and community members during this era:
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ward0g
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Yamete
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Elmas
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Floppa (Cubical)
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HypR Kirito
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Asmog
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Devils Garden
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Gordon Ramsey
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Mody
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Flori GG
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NerdOwner
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Yackio
https://media.rankstone.org/HypR-Modded-Github.png
(Note: If you were active during this era of the game, leave a reply to this thread so your name and any missing facts can be added to the historical record.)
You've reached the end!